HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Azidomethyl)-8-chloro-2-(5-fluoro-2-methoxyphenyl)quinoline → (8-Chloro-2-(5-fluoro-2-methoxyphenyl)quinoline-3-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Azidomethyl)-8-chloro-2-(5-fluoro-2-methoxyphenyl)quinoline | HCID 57707988 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (8-Chloro-2-(5-fluoro-2-methoxyphenyl)quinoline-3-yl)methanamine | HCID 57707949 | — |
Reaction Steps
To a stirred solution of 3-(azidomethyl)-8-chloro-2-(5-fluoro-2-methoxyphenyl)-quinoline (210.7 mg, 615 μmol) in THF 5 mL and MeOH 12 mL was added palladium, 10 wt. % on activated carbon (0.329 mmol) and placed under a medium balloon containing H2. The reaction was complete after 2 h, it was filtered (Celite™) and solvents removed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901135B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-ec925e82a6ae4bf1816cc31b9350d81a |
| Source note | uspto-grants-2014_12 |