Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Purine, 6-bromo- | HCID 5287830 | — |
| Reactant | (1S)-1-(8-chloro-2-(6-methylpyridin-2-yl)quinolin-3-yl)-ethanamine | HCID 57707942 | — |
| Product | HCID 178424622 | HCID 178424622 | — |
Reaction Steps
To a stirred solution of (1S)-1-(8-chloro-2-(6-methylpyridin-2-yl)quinolin-3-yl)-ethanamine (146 mg, 0.49 mmol) in 1-butanol (5.4 mL, 59 mmol) was added 6-bromopurine (0.107 g, 0.54 mmol) and N,N-diisopropylethylamine (0.17 mL, 0.98 mmol) with heating (110° C.) overnight. solvents were removed and the residue subjected to chromatography, gradient, 89:9:1(DCM:MeOH:NH4OH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08901135B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-9e0b9bfe43f5476dab1796b91e241014 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
