Sodium borohydride → HCID 57707816, compound

Participants

Reaction Steps

Sodium borohydride (0.159 g, 4.20 mmol) was added portion wise to a stirring solution of 8-chloro-2-(2-fluorophenyl)quinoline-3-carbaldehyde (0.800 g, 2.80 mmol) in 15 mL of THF. The reaction stirred at room temperature. After 1.5 h, the mixture was partitioned between water and EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure: LC-MS (ESI) m/z 288.1 [M+H]+. The crude product was carried on crude without purification for the next step.

Provenance & Evidence