Water → 1,1-Dimethylethyl N-[2-[[[(4-aminophenyl)amino]carbonyl]amino]ethyl]carbamate

Participants

Reaction Steps

Piperidine (9.68 mL, 97.75 mmol, 5.0 eq) was added at room temperature to a stirred solution of N-{4-[({2-[(tert-butoxy)carbonylamino]ethyl}amino)carbonylamino]phenyl}(fluoren-9-ylmethoxy)carboxamide (10.10 g, 19.55 mmol, 1.0 eq) in DMF (140 mL). After 2 hours stirring at room temperature, water was added to the reaction mixture and precipitation α-cured. The resulting mixture was filtered, and the liquid phase was concentrated to afford 6.75 g of the expected product as an orange oil:

Provenance & Evidence