Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)benzoate → 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid

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Reaction Steps

To 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester (5, 2.0 g, 5.4 mmol) in 30 mL of methanol, 20% palladium hydroxide on carbon (100 mg) was added. The reaction was stirred under hydrogen at 1 atm for 15 minutes. The reaction was filtered and the filtrate concentrated under vacuum to give the desired compound as a white solid (6) that was used in the next step without further purification.

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