HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,6-Difluoro-3-(propane-1-sulfonylamino)-benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid | HCID 46192923 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,6-Difluoro-3-(propane-1-sulfonylamino)-benzoyl chloride | HCID 58086861 | — |
Reaction Steps
To 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid (6, 1.50 g, 5.4 mmol), 7.0 mL of toluene and thionyl chloride (15.0 mL, 0.21 mmol) were added. The reaction was heated to reflux for 3 hours, then concentrated to give crude compound (7) that was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901301B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3e13a0a8e64e48948472474ce3d95b0a |
| Source note | uspto-grants-2014_12 |