Water → 6-Chloro-2-fluoro-(propane-1-sulfonylamino)-benzoic acid benzyl ester

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Reaction Steps

To 3-amino-6-chloro-2-fluoro-benzoic acid benzyl ester (16, 1.20 g, 4.3 mmol) in 28 mL of dichloromethane, pyridine (0.52 mL, 6.4 mmol) and propane-1-sulfonyl chloride (4, 0.685 g, 4.8 mmol) were added. The reaction was stirred at room temperature overnight, then poured into water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under vacuum. The desired compound was isolated with silica gel column chromatography to give a colorless oil (17, 960 mg, 58.0%). MS(ESI) [M−H+]−=384.1.

Provenance & Evidence