Triacetoxyperiodinane → HCID 46913050, compound

Participants

Reaction Steps

To propane-1-sulfonic acid {3-[(5-cyano-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2-fluoro-phenyl}-amide (23, 77 mg, 0.20 mmol) dissolved in 1 mL of tetrahydrofuran, Dess-Martin periodinane (92.5 mg, 0.218 mmol) was added as a solid. The reaction was stirred at room temperature for 1 hour, then quenched with water. The aqueous layer was separated and extracted with ethyl acetate, and the organice layers combined, washed with brine, dried over sodium sulfate and filtered. The filtrate was concentrated under vacuum and the resulting residue was purified by silica gel column chromatography eluting with ethyl acetate and hexanes to provide the desired compound (P-0003, 67 mg). MS(ESI) [M−H+]−=385.4.

Provenance & Evidence