Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | L-m-tyrosine | HCID 6950578 | — |
| Product | Hydrochloric Acid | HCID 313 | 99% |
| Product | Ethyl 2-amino-3-(3-hydroxyphenyl)propanoate | HCID 13890117 | — |
Reaction Steps
To 20 mL of EtOH at −5° C. was added, with stirring, 0.2 mL of SOCl2 slowly. The clear colorless solution was cooled to −5° C. and 510 mg of meta-Tyrosine was added. After 5 min, the resulting solution was refluxed overnight. The solution was concentrated to afford 157 as HCl salt (690 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08901295B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-1531da5aaa3a42d68c3bd7a3f1fefcd0 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
