反应详情

A solution of 174 (410 mg) in MeOH (20 ml) was stirred for 1 h under hydrogen atmosphere in the presence of 10% Pd/C. The resulting mixture was filtered through celite and the filtrate was evaporated under reduced pressure to give 175 as white solid (280 mg, 97%). 1H NMR (DMSO): δ 1.61 (s, 9H), 2.93 (m, 1H), 3.05 (m, 1H), 4.23 (m, 2H), 4.38 (m, 1H), 6.17 (d, 1H, J=8.0 Hz), 6.66 (t, 1H, J=5.9 Hz), 7.16 (t, 1H, J=7.3 Hz), 7.22 (d, 2H, J=7.6 Hz), 7.50 (d, 2H, J=7.6 Hz), 9.38 (s, 1H).

1. filtrationThe resulting mixture was filtered through celite
2. customthe filtrate was evaporated under reduced pressure