HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-N-methylaniline → 4-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-N-methylaniline | HCID 68024 | — |
| Reactant | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| Product | 4-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzoic acid | HCID 56687146 | — |
Reaction Steps
4-(chlorosulfonyl)benzoic acid (0.5 g, 2.27 mmol) was treated with 4-fluoro-N-methylaniline (851 mg, 6.80 mmol) using method A to give 4-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzoic acid as a white solid. Yield: 534 mg (76%). 1H-NMR: 8.10 (d, J=8.5 Hz, 2H), 7.62 (d, J=8.5 Hz, 2H), 7.23-7.11 (m, 4H), 3.15 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901306B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-167b1d5273bf42fab6e3530be61e2f39 |
| Source note | uspto-grants-2014_12 |