HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → Tirbanibulin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Methyl 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetate | HCID 44185422 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | Tirbanibulin | HCID 23635314 | — |
Reaction Steps
The resulting methyl 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetate (7) and benzyl amine were coupled in anisole at high temperature to afford 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (KX2-391). An HCl solution formed by adding acetyl chloride to absolute ethanol was added to KX2-391 to form the bis-HCl salt, 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide dihydrochloride, (KX2-di-HCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901297B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2831c58afc4947d8be4838146511b82e |
| Source note | uspto-grants-2014_12 |