反应详情

To a solution of 1-{4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-phenyl}-ethanone (Example 12) (20 mg, 0.05 mmol) in 1 mL of ethanol was added sodium borohydride (1.8 mg, 0.05 mmol) and the mixture stirred for 1 hr at RT. The solution was diluted with 5 mL of 50% CH3CN in 0.1% TFA/H2O and purified by RP-HPLC, eluting with a linear gradient of 50%-100% CH3CN in 0.1% TFA/H2O over 10 mins to give 20 mg (86%) of the title compound a white solid containing 0.5 eq of TFA.

1. custompurified by RP-HPLC
2. washeluting with a linear gradient of 50%-100% CH3CN in 0.1% TFA/H2O over 10 mins