HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2,2-dimethyltetrahydro-2H-pyran-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid | HCID 3337663 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,2-dimethyltetrahydro-2H-pyran-4-carbonyl chloride | HCID 12296413 | — |
Reaction Steps
To a solution of 2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid (530 mg, 3.35 mmol) in 10 mL of DCM at 0° C. was added 1 drop of DMF followed by oxalyl chloride (0.33 mL, 3.69 mmol) and the reaction stirred at RT for 3 hrs. The reaction was then concentrated and used with out further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901314B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-206262bb2158422586947f5d7decc2a8 |
| Source note | uspto-grants-2014_12 |