HCID 73291873, compound → HCID 73291872, compound

Participants

Reaction Steps

A solution of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyl-2,5-dihydrofuran-3-yl)-1H-pyrazole (162 mg, 0.4 mmol, 1 eq) (Example 67) and PtO2 (9 mg, 0.04 mmol, 0.1 eq) in ethyl acetate (10 mL) was put under a balloon of H2 and stirred overnight. Additional PtO2 (9 mg) was then added and the reaction stirred for 3 more days under a balloon of H2. The reaction was filtered through Celite, and concentrated. Purification by HPLC eluting with 30 to 100% acetonitrile/H2O gave the title compound (70 mg, 41%).

Provenance & Evidence