Iodoethane → HCID 73294553, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline (Example 70) (25 mg, 0.06 mmol, 1 eq) in acetone (2 mL) was added potassium carbonate (84 mg, 0.6 mmol, 10 eq) and iodoethane (0.049 mL, 0.6 mmol, 10 eq), the solution heated to 60° C. overnight. The reaction was 50% complete, added iodoethane (0.049 mL) and heated to 60° C. overnight. Added water, extracted with DCM, dried over MgSO4 and concentrated. Purification by silica gel column chromatography (8 g) eluting with 7 to 15% EtOAc/hex, then purification by RP-HPLC eluting with 10 to 100% acetonitrile/H2O gave the title compound (12.4 mg, 46%).

Provenance & Evidence