反应详情

To a solution of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole (80 mg, 0.19 mmol)(Example 1) in 2 mL of DCM was added NBS (33 mg, 0.19 mmol) and the mixture stirred for 30 mins at Rt. The crude product was purified by silica gel chromatography (Thomson Scientific 12-g cartridge, 2-20% EtOAc/heptane) to give 40 mg (40%) of the title compound.

1. customThe crude product was purified by silica gel chromatography (Thomson Scientific 12-g cartridge, 2-20% EtOAc/heptane)