Dimethylcarbamoyl Chloride → HCID 53256180, compound

Participants

Reaction Steps

To a solution of 500 mg (2.50 mmol) of tert-butyl 4-piperidinylcarbamate in 20 mL of dichloromethane was added 522 μL (3.74 mmol) of triethylamine and 276 μL (3.00 mmol) of dimethylaminocarbonyl chloride and the mixture was stirred for 2 hours at room temperature. Then, the mixture was treated with ethyl acetate and the organic layer was washed with water and saturated saline solution, and then, dried over with anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 636 mg (94%) of the title compound.

Provenance & Evidence