反应详情

A solution of Benzyloxycarbonyl methoxy-acetic acid (40 g) and Thionyl Chloride (80 ml) was stirred at reflux temperature for 3 hours. Excess Thionyl Chloride was distilled off and to the residue was added Toluene (100 ml). The solvent was distilled off completely to get chlorocarbonyl methoxy-acetic acid benzyl ester (40 g) as a light brown liquid which was used without further purification.

1. temperatureat reflux temperature for 3 hours
2. distillationExcess Thionyl Chloride was distilled off and to the residue
3. additionwas added Toluene (100 ml)
4. distillationThe solvent was distilled off completely