Ethyl Acetate → 4-(4-bromo-1H-imidazol-1-yl)-3-methoxybenzoic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of methyl 4-fluoro-3-methoxybenzoate (2.13 g), 4-bromo-1H-imidazole (3.74 g) and potassium carbonate (4.80 g) in DMF (20 mL) was stirred at 100° C. overnight, and allowed to cool to room temperature, and ethyl acetate and water were added. The aqueous layer was separated, and acidified with 6N hydrochloric acid (pH=3-4), and the resultant precipitate was collected by filtration to give the title compound (1.92 g).

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