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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1398225Generated: November 1, 2026

Hydrazine hydrate (1:1) → HCID 66608309, compound

https://huagongshe.com/reaction/1398225

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactantmethyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzoateHCID 66608175—
SolventMethanolHCID 887—
ProductHCID 66608309HCID 66608309—

Reaction Conditions

Temperature60 °C

Reaction Steps

To a mixture of methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzoate (25.5 mg) in methanol (1 mL) was added hydrazine monohydrate (0.019 mL) at room temperature, the mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901309B2
Source datasetuspto-grants-2014_12
ORD IDord-850e22966f7046f4999778f51253a334
Source noteuspto-grants-2014_12