HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1398245Generated: November 1, 2026
Ethanol → Ethyl (3,4,5-trifluoro-2-hydroxyphenyl)acetate
https://huagongshe.com/reaction/1398245
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (3,4,5-Trifluoro-2-hydroxyphenyl)acetic acid | HCID 84673812 | — |
| Product | Ethyl (3,4,5-trifluoro-2-hydroxyphenyl)acetate | HCID 86662985 | — |
Reaction Steps
A mixture of (3,4,5-trifluoro-2-hydroxyphenyl)acetic acid (6.0 g), sulfuric acid (0.016 mL) and ethanol (50 mL) was stirred at 80° C. overnight, neutralized with saturated aqueous sodium hydrogen carbonate solution, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (5.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08901309B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-dd202428e96142debf59b226eb02b072 |
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| Source note | uspto-grants-2014_12 |
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