HCID 117716334, compound → HCID 86294322, compound

Participants

Reaction Steps

6-(4-nitrophenoxy)-hexanoic acid 4-nitrophenyl ester (20 g) was dissolved in ethyl acetate (150 ml) in a pressure vessel. Palladium on carbon (50% wet, 3 grams) was added as a catalyst and the mixture was stirred under an atmosphere of hydrogen (5 Kg) for 1 hour. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure, and the residue was triturated with cold hexane, filtered, and dried to give pure 6-(4-aminophenoxy)-hexanoic acid 4-amino-phenyl ester (11 grams) as off-white powder with a melting point of 99-101° C. The product was characterized by 1H NMR (CDCl3) δ 1.60 (m, 2H, CH2), 1.85 (m, 6H, CH2X2), 2.55 (t, 2H, CH2), 3.50 (bs, 4H, NH2), 3.90 (t, 2H, CH2), 6.60 to 6.90 (m, 8H, Ar).

Provenance & Evidence