HCID 117716329, compound → HCID 86294320, compound

Participants

Reaction Steps

2-(4-nitrophenoxy)-propionic acid 4-nitrophenyl ester (30 grams, 90.28 mmoles) was dissolved in ethyl acetate (600 ml) in a pressure vessel, palladium on carbon (50% wet, 6 grams) was added and the mixture stirred under an atmosphere of Hydrogen (5 Kg) for 30 minutes. The catalyst was removed by filtration and the solvent distilled off under reduced pressure. The residue was triturated in cold diisopropyl ether, filtered and dried to give pure 2-(4-aminophenoxy)-propionic acid 4-amino-phenyl ester (15 grams) as off-white powder. The product has a melting point of 109-111° C. The product was characterized by 1H NMR (CDCl3) δ 1.75 (d, 3H, CH3), 3.50 (bs, 2H, NH2), 4.90 (q, 1H, CH), 6.65 (m, 4H, Ar), 6.80 (m, 4H, Ar).

Provenance & Evidence