HCID 117716267, compound → HCID 117716311, compound

Participants

Reaction Steps

(4-Nitrophenoxy)-propionic acid 2-{2-[2-(4-nitrophenoxy)-propionyloxy]-ethoxy}-ethyl ester (300 g) was dissolved in ethyl acetate (1.5 L) in a pressure vessel. Raney Nickel catalyst (290 g) was added and the mixture was stirred under an atmosphere of hydrogen (10 Kg) for 4 hour. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure to obtain pure (4-aminophenoxy)-propionic acid 2-{2-[2-(4-aminophenoxy)-propionyloxy]-ethoxy}-ethyl ester (254 g) as a light yellow syrup. The product was characterized by 1H NMR (CDCl3) δ 1.60 (d, 3H, CH3), 3.20 (bs, 2H, NH2), 3.60 (t, 2H, CH2), 4.25 (t, 2H, CH2), 4.65 (q, 1H, CH), 6.60 (d, 2H, Ar), 6.75 (d, 2H, Ar).

Provenance & Evidence