Water → HCID 117716545, compound

Participants

Reaction Steps

Into a 3-liter 4-neck round bottom flask equipped with a mechanical stirrer was added a solution of diethylene glycol (100 g), 6-Bromo hexanoic acid (386 g) and para-toluene sulphonic acid (5 g) in toluene (1000 ml). The solution was refluxed for 3 hours in a Dean-Stark apparatus with azeotropic removal of water. The solution was cooled to room temperature and the toluene layer was washed with water (600 ml), 5% sodium bicarbonate solution (1500 ml) and water (600 ml). The toluene layer was dried over anhydrous sodium sulphate, filtered and distilled to obtain 6-bromohexanoic acid 2-[2-(6-bromohexanoyloxy)-ethoxy]-ethyl ester (400 g) as light yellow oil.

Provenance & Evidence