反应详情

To a solution of 6-bromo-3-methylindazole (300 mg, 1.42 mmol) in DMF (6 mL) was added NaH (60% oil suspension) (91 mg, 2.27 mmol) at 0° C. The mixture was stirred at RT for 10 min before addition of 4-chloropyrimidin-2-amine (368 mg, 2.84 mmol). Stirring continued at 60° C. for 2 hr. After standing at RT overnight the reaction mixture was quenched by addition of water (10 mL). The mixture was extracted with EtOAc (2×15 mL). During the process of extraction solid formed was removed by suction filtration. The organic layer was washed with water (2×5 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was triturated with EtOAc-heptane (1:1) to give the title intermediate as a white solid: 1H NMR (250 MHz, DMSO) δ 2.53-2.64 (3H, m), 6.69-7.21 (3H, m), 7.43-7.62 (1H, m), 7.76-7.89 (1H, m), 8.18-8.38 (1H, m), 8.92-9.15 (1H, m); LC-MS: m/z=+303.95/305.65 (M+H).

1. waitAfter standing at RT overnight
2. customthe reaction mixture was quenched by addition of water (10 mL)
3. extractionThe mixture was extracted with EtOAc (2×15 mL)
4. extractionDuring the process of extraction solid
5. customformed
6. customwas removed by suction filtration
7. washThe organic layer was washed with water (2×5 mL)
8. dry with materialdried over Na2SO4
9. filtrationfiltered
10. concentrationconcentrated in vacuo
11. customThe residue was triturated with EtOAc-heptane (1:1)