HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-butyn-2-ol → HCID 60164162, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-butyn-2-ol | HCID 8258 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 68181751 | HCID 68181751 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 60164162 | HCID 60164162 | — |
Reaction Steps
To a pressure tube was added 4-(6-iodo-1H-indazol-1-yl)-N-(2-methoxypyridin-3-yl)-1,3,5-triazin-2-amine (100 mg, 0.22 mmol), followed by triethylamine (0.7 mL) and THF (0.7 mL). Copper(I) iodide (4.28 mg, 0.022 mmol), PdCl2(PPh3)2 (15.76 mg, 0.022 mmol) and 2-methylbut-3-yn-2-ol (0.04 ml, 0.45 mmol) were then added and the reaction vessel was sealed and stirred at RT for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901313B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-65d3d917cb814e1f89ae39610d7883ad |
| Source note | uspto-grants-2014_12 |