2-Methyl-3-butyn-2-ol → HCID 68181720, compound

Participants

Reaction Steps

The title compound was prepared by the procedure described in Example 10-c by substituting 4-{6-bromo-3-[(dimethylamino)methyl]-1H-indazol-1-yl}pyrimidin-2-amine with of 4-{6-bromo-3-[(3,3-difluoroazetidin-1-yl)methyl]indazol-1-yl}pyrimidin-2-amine and 2-methyl-but-3-yn-2-ol with (2R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol: 1H NMR (500 MHz, CDCl3) delta 2.09 (3H, s), 2.67 (3H, s), 3.73 (4H, t, J=12.06 Hz), 4.12 (2H, s), 4.80-5.13 (1 H, m), 5.51 (2H, s), 7.28 (1H, d, J=5.67 Hz), 7.37 (1H, dd, J=8.28, 1.02 Hz), 7.79 (1H, d, J=8.20 Hz), 8.30 (1H, d, J=5.67 Hz), 8.86 (1H, s); LC-MS: m/z=+467.1 (M+H)+.

Provenance & Evidence