(R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol → HCID 60164950, compound

Participants

Reaction Steps

The title compound was prepared by procedure described in Example 62-c, by substituting 1-(2-aminopyrimidin-4-yl)-6-bromo-N,N-dimethylindazole-3-carboxamide with 1-(2-aminopyrimidin-4-yl)-6-bromo-N-methylindazole-3-carboxamide and 2-(1,3-thiazol-2-yl)but-3-yn-2-ol with (2R)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol in Step 3: 1H NMR (500 MHz, DMSO) delta 1.87 (3H, s), 2.42 (3H, s), 2.87 (3H, d, J=4.73 Hz), 6.42 (1H, s), 6.60 (1H, s), 7.17 (2H, br. s.), 7.32 (1H, d, J=5.36 Hz), 7.46 (1H, dd, J=8.35, 1.10 Hz), 8.27 (1H, d, J=8.20 Hz), 8.40 (1H, d, J=5.36 Hz), 8.78 (1H, d, J=4.73 Hz), 8.94 (1H, s); LC-MS: m/z=+418.05 (M+H)+.

Provenance & Evidence