2-Methyl-3-butyn-2-ol → HCID 60164283, compound

HRID 1398638Notes

Reaction equation

HRID 1398638 reaction equation
[IH+][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[C:11]2[N:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)=[CH:4][CH:3]=1.[CH3:18][C:19]([OH:23])([C:21]#[CH:22])[CH3:20]>>[NH2:17][C:13]1[N:14]=[CH:15][N:16]=[C:11]([N:8]2[C:9]3[C:5](=[CH:4][CH:3]=[C:2]([C:22]#[C:21][C:19]([CH3:20])([OH:23])[CH3:18])[CH:10]=3)[CH:6]=[N:7]2)[CH:12]=1

Participants

3

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 86669605HCID 86669605, compound

Product 1

HCID 60164283HCID 60164283, compound

Procedure

The title compound was prepared by the procedure described in Example 1-b by reacting 6-(6-iodomoindazol-1-yl)pyrimidin-4-amine with 2-methylbut-3-yn-2-ol: 1H NMR (500 MHz, DMSO) delta 1.50 (6H, s), 5.56 (1H, s), 6.95 (1H, s), 7.10 (2H, br. s.), 7.29 (1H, dd, J=8.20, 1.26 Hz), 7.86 (1H, d, J=8.20 Hz), 8.46 (2H, d, J=9.30 Hz), 8.81 (1H, s); LC-MS: m/z=+294.50.

Sources & evidence

ORD record
ord-182e0530c13d48559cf0515ec03fbebb
Source dataset
uspto-grants-2014_12
Patent number
US08901313B2

Reaction notes

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