2-Methyl-3-butyn-2-ol → 4-[1-(2-aminopyrimidin-4-yl)-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-6-yl]-2-methylbut-3-yn-2-ol

Participants

Reaction Steps

The title compound was prepared by the method described in Example 142-b, by reacting 4-[6-bromo-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine with 2-methyl-3-butyn-2-ol: 1H NMR (DMSO, 500 MHz) delta 1.46 (6H, s), 4.73 (2H, dd, J=7.9, 4.9 Hz), 4.94 (2H, t, J=7.1 Hz), 5.40 (1H, s), 5.94-5.68 (1H, m), 7.17-6.99 (3H, m), 7.21 (1H, dd, J=8.2, 1.6 Hz), 7.41 (1H, d, J=8.2 Hz), 8.14 (1H, d, J=1.0 Hz), 8.39 (1H, d, J=5.5 Hz); LC-MS: m/z=+366.1 (M+H)+.

Provenance & Evidence