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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1398655Generated: October 26, 2026

4-[6-Bromo-2-(oxetan-3-yloxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine → 4-[6-Iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine

https://huagongshe.com/reaction/1398655

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[6-Bromo-2-(oxetan-3-yloxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amineHCID 68181588—
Reactant4-[6-iodo-2-(trichloromethyl)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amineHCID 68181943—
Solvent2-MethoxyethanolHCID 8019—
Product4-[6-Iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amineHCID 68181597—

Reaction Steps

The title compound was prepared by the procedure described for the synthesis of 4-[6-bromo-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine by reacting 4-[6-iodo-2-(trichloromethyl)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine with 2-methoxyethanol: LC-MS: m/z=+412 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901313B2
Source datasetuspto-grants-2014_12
ORD IDord-e7b5da260bac4021909c7a224afd213c
Source noteuspto-grants-2014_12