Triethylamine → HCID 68181617, compound

Participants

Reaction Steps

A mixture of 4-[2-(azetidin-3-yloxy)-6-bromo-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine (2 g, 0.44 mmol, 8% purity) and triethylamine (1.5 mL) in 2-bromoethan-1-ol (1.5 mL) was stirred at room temperature for 12 h. The reaction mixture was purified on a C18 column (water/acetonitrile, 5:95-80:20) to yield 100 mg (50%) of 2-(3-[[1-(2-aminopyrimidin-4-yl)-6-bromo-1H-1,3-benzodiazol-2-yl]oxy]azetidin-1-yl)ethan-1-ol as a yellow solid: LC-MS: m/z=+405 (M+H)+.

Provenance & Evidence