Tetrabutylammonium Fluoride → HCID 68181509, compound

Participants

Reaction Steps

In a solution of 3-[3-(4-amino-[1,3,5]triazin-2-yl)-2-methyl-3H-benzoimidazol-5-yl]-1-[3-(tert-butyl-dimethyl-silanyloxy)-cyclobutyl]-prop-2-yn-1-ol (50 mg, 0.1 mmol) in tetrahydrofuran (20 ml) was added tetrabutylammonium fluoride (70 mg, 0.3 mmol). Then the solution stirred overnight at room temperature. The reaction mixture was washed with water and purified by column to afford title compound (20 mg, 57%): 1H NMR (400 MHz, MeOD) delta 1.80-2.20 (m, 3H), 2.32-2.43 (m, 2H), 2.94 (s, 3H), 3.56-3.70 (m, 0.5H), 4.05-4.17 (m, 0.5H), 4.45-4.48 (m, 0.5H), 7.35-7.51 (m, 2H), 8.53-8.57 (m, 2H). LCMS: m/z=+350.9 (M+H)+.

Provenance & Evidence