HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 3,4,5-tris(benzyloxy)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Serotonin Hydrochloride | HCID 160436 | — |
| Reactant | 3,4,5-Tris(benzyloxy)benzoic Acid | HCID 11133969 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,4,5-tris(benzyloxy)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)benzamide | HCID 66803730 | — |
Reaction Steps
2a was synthesized by the condensation of 3,4,5-tris(benzyloxy)benzoic acid (860 mg, 1.95 mmol) and 5-hydroxy tryptamine hydrochloride (496 mg, 2.34 mmol) according using standard EDC coupling method. The compound was isolated as white solid (874 mg, 75%) by elution with 2% methanol in chloroform. Rf: 0.470 (5% methanol in chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901317B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-169cd1b1db5148dd9541f1c282a88224 |
| Source note | uspto-grants-2014_12 |