HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-Coumaroyl serotonin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 4-Coumaric acid | HCID 322 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Serotonin Hydrochloride | HCID 160436 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | N-Coumaroyl serotonin | HCID 5458879 | — |
Reaction Steps
(E)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-3-(4-hydroxyphenyl)acrylamide (2b) was synthesized according to by the condensation of 4-hydroxy cinnamic acid (150 mg, 0.914 mmol) and 5-hydroxy tryptamine hydrochloride (232 mg, 1.09 mmol) using standard EDC coupling method. 2b was isolated as reddish semi solid (182 mg 62%) by elution with 55% ethyl acetate in hexane. Rf: 0.58 (ethyl acetate);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901317B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-cf67d0f9f5cb49c8a598038d401cb48d |
| Source note | uspto-grants-2014_12 |