1,2-Dichloroethane → 53905-12-7

Participants

Reaction Steps

(E)-N-(2-(1H-indol-3-yl)ethyl)-3-(4-hydroxyphenyl) acrylamide (2e) was synthesized by the condensation of 4-hydroxy cinnamic acid (150 mg, 0.914 mmol) and tryptamine hydrochloride (215 mg, 1.09 mmol) using standard EDC coupling method. 2e was isolated as yellowish solid (178 mg, 64%) by elution with 45% ethyl acetate in hexane. Rf: 0.593 (80% ethyl acetate in hexane); mp: 135-138° C.;

Provenance & Evidence