2-Bromo-5-propylthiophene → 2-(4'-Ethyl-2,6-difluorobiphenyl-4-yl)-5-propylthiophene

HRID 1399413Notes

Reaction equation

HRID 1399413 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([F:15])=[CH:13][C:12](B(O)O)=[CH:11][C:10]=2[F:19])=[CH:5][CH:4]=1)[CH3:2].Br[C:21]1[S:22][C:23]([CH2:26][CH2:27][CH3:28])=[CH:24][CH:25]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([F:15])=[CH:13][C:12]([C:21]3[S:22][C:23]([CH2:26][CH2:27][CH3:28])=[CH:24][CH:25]=3)=[CH:11][C:10]=2[F:19])=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 218019042-Bromo-5-propylthiopheneHCID 666251904'-Ethyl-2,6-difluoro-4-biphenylboronic acid

Product 1

HCID 580284442-(4'-Ethyl-2,6-difluorobiphenyl-4-yl)-5-propylthiophene

Procedure

The compound 2-(4′-ethyl-2,6-difluorobiphenyl-4-yl)-5-propylthiophene (SUP-3-2) is prepared analogously to Example 1 from 4′-ethyl-2,6-difluoro-4-biphenylboronic acid and 2-bromo-5-propylthiophene.

Sources & evidence

ORD record
ord-3886fd819f744c7da1b29ad3e12bcc09
Source dataset
uspto-grants-2014_12
Patent number
US08906261B2

Reaction notes

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