2-Bromo-5-vinylthiophene → 2-(3,5-Difluoro-4'-propylbiphenyl-4-yl)-5-vinylthiophene

HRID 1399415Notes

Reaction equation

HRID 1399415 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([F:16])[C:13](B(O)O)=[C:12]([F:20])[CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].Br[C:22]1[S:23][C:24]([CH:27]=[CH2:28])=[CH:25][CH:26]=1>>[F:20][C:12]1[CH:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=2)[CH:15]=[C:14]([F:16])[C:13]=1[C:22]1[S:23][C:24]([CH:27]=[CH2:28])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 130520522-Bromo-5-vinylthiopheneHCID 580284314'-Propyl-3,5-difluoro-4-biphenylboronic acid

Product 1

HCID 580284432-(3,5-Difluoro-4'-propylbiphenyl-4-yl)-5-vinylthiophene

Procedure

The compound 2-(3,5-difluoro-4′-propylbiphenyl-4-yl)-5-vinylthiophene (PUS-3-V) is prepared analogously to Example 3 from 4′-propyl-3,5-difluoro-4-biphenylboronic acid and 2-bromo-5-vinylthiophene.

Sources & evidence

ORD record
ord-2f5d5a5894e8434aa59ebabc8acdc109
Source dataset
uspto-grants-2014_12
Patent number
US08906261B2

Reaction notes

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