Sodium Carbonate → (R)-2-(2,6-Dinitrobenzamido)propanoic acid

関与物質

反応手順

The reaction of 2,6-dinitrobenzoyl chloride (prepared from 2,6-dinitrobenzoic acid, 1.4 g and SOCl2, 15 mL) with D-alanine (0.7 g, 7.92 mmol) in the presence of Na2CO3 (0.83 g, 7.92 mmol) as described in intermediate 2 gave the title compound as a pale brown color solid (1.58 g, 85%), mp 202-204° C. 1H NMR (400 MHz, DMSO-d6): δ 12.79 (1H, br s), 9.24 (1H, d, J=7.6 Hz), 8.45 (2H, d, J=8.4 Hz), 7.93 (1H, t, J=8.4 Hz), 4.48 (1H, pentet, J=7.3 Hz), 1.33 (3H, d, J=7.2 Hz); LC-MS (negative ion mode): m/z 282 (M−H)−.

情報源と証拠