HCID 86713119, compound → HCID 86713109, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl 2-(2-chloro-4-fluoro-5-nitrobenzamido)acetate (190 mg) in EtOAc (10 mL) was added Pd/C (200 mg) and stirred under the atmosphere of H2 gas at 60° C. for 20 min. Work-up of the reaction mixture as described in example 1 gave the product as an off-white solid (86 mg, 67%), mp 225-227° C. (decomposed). 1H NMR (400 MHz, DMSO-d6): δ 8.52 (1H, br s), 7.19 (1H, d, J=10.8 Hz), 6.89 (1H, d, J=9.2 Hz), 5.48 (2H, br s), 3.86 (2H, d, J=3.6 Hz); LC-MS (negative ion mode): m/z 245, 247 (M−H)−.

Provenance & Evidence