Trifluoroacetic acid → HCID 131732131, compound

Participants

Reaction Conditions

Reaction Steps

N-Boc-ethylenediamine (81 μl, 0.51 mmol) was added to a solution of Br—(CH2)5—CONH—(CH2)2-STrt (230 mg, 0.46 mmol) and Na2CO3 (196 mg, 1.85 mmol) in DMF (0.8 ml). The reaction mixture was stirred for 10 h at 70° C. After cooling to RT the mixture was diluted with 4 ml (MeCN/H2O=25:75, with 0.1% TFA) and purified by RP-HPLC to get Boc-NH—(CH2)2—NH—(CH2)5—CONH—(CH2)2-STrt.

Provenance & Evidence