Formaldehyde → HCID 131732132, compound

Participants

Reaction Steps

Boc-NH—(CH2)2—NH—(CH2)5—CONH—(CH2)2-STrt (189 mg, 0.27 mmol) and HCHO (35% aqueous, 113 μl) were dissolved in MeCN (1.5 ml) and NaCNBH3 (34 mg, 0.54 mmol) was added. The reaction mixture was stirred for 5 h at RT. After completion of the reaction (MS) the solution was diluted with H2O (5 ml) and extracted with CH2Cl2 (3×5 ml). The combined organic layers were dried over MgSO4, filtered and the solvent was removed in vacuo. The residue was purified by RP-HPLC to get Boc-NH—(CH2)2—N(CH3)—(CH2)5—CONH—(CH2)2-STrt.

Provenance & Evidence