HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylazanium;formate → H2N-(CH2)2-N(Boc)-(CH2)2-CONH-(CH2)2-STrt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylazanium;formate | HCID 10219518 | — |
| Reactant | Alloc-NH-(CH2)2-N(Boc)-(CH2)2-CONH-(CH2)2-STrt | HCID 131732134 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | H2N-(CH2)2-N(Boc)-(CH2)2-CONH-(CH2)2-STrt | HCID 70987991 | — |
Reaction Steps
Alloc-NH—(CH2)2—N(Boc)-(CH2)2—CONH—(CH2)2-STrt (48.3 mg, 0.078 mmol) was dissolved in THF, triethylammoniumformate (62 μl) and Pd(PPh3)4 (16 mg) were added. The solution was stirred for 12 h at RT and monitored by MS. After completion the solvent was removed in vacuo. The residue was dissolved in MeCN/H2O (50:50, with 0.1% TFA) and purified by RP-HPLC to give H2N—(CH2)2—N(Boc)-(CH2)2—CONH—(CH2)2-STrt (31).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08906847B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-8da5eb13bb2648c996d4ada83fa5161e |
| Source note | uspto-grants-2014_12 |