Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-[(Z)-[2-[[(6R,7R)-3-[[5-amino-4-(2-aminoethylcarbamoylamino)-1-methylpyrazol-2-ium-2-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate | HCID 71457955 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 49863419 | HCID 49863419 | — |
Reaction Steps
A ceftolozane sulfate composition can be obtained by a process comprising the steps of: (a) forming a solution comprising water, 72-100 g/L ceftolozane active and 1.5-2.95 molar equivalents of sulfuric acid to ceftolozane; (b) combining the solution from step (a) with 20-40 volumes of isopropyl alcohol added to the solution over 0.5-8 hours to obtain solid ceftolozane sulfate; and (c) isolating the solid ceftolozane sulfate from the solution. The temperature of the solution can be about 0-20 degrees C., preferably 8-12 degrees C. (e.g. 10 degrees C.). Optionally, the process can further include adding a ceftolozane sulfate seed crystal, preferably in an amount of 0.03-4.0% w/w and allowing the seed crystal to age in the solution for about 1-5 hours. Optionally, the process can include allowing the solution to age for up to about 8 hours after adding the isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08906898B1 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-cd41226214584383926d0e404e2e4866 |
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| Source note | uspto-grants-2014_12 |
|---|
