HRID1399545

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID72879

Methanesulfonamide

CH5NO2S

$结构：C/C=C(\O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1$

HCID11300561

未命名化合物

结构：CC[C@@H]1CN2CC[C@@H]1C[C@@H]2[C@H](Oc1nnc(O[C@H](c2ccnc3ccc(OC)cc23)[C@H]2C[C@@H]3CCN2C[C@@H]3CC)c2ccccc12)c1ccnc2ccc(OC)cc12

HCID51003674

(3alpha)-6'-Methoxy-9-[(4-{[(4beta)-6'-methoxy-10,11-dihydrocinchonan-9-yl]oxy}phthalazin-1-yl)oxy]-10,11-dihydrocinchonan

C48H54N6O4

PRODUCTS

生成物

HCID10313420

(2S)-1-(3-chlorophenyl)-2-hydroxypropan-1-one

C9H9ClO2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID71401949

2-Methylpropan-2-ol--water (1/1)

C4H12O2

PROCEDURE

实验过程

Compound (S)-10a was synthesized by a procedure similar to that described for (R)-10a using (Z)-tert-butyl(1-(3-chlorophenyl)prop-1-enyloxy)dimethylsilane (9a, 8.8 g, 0.031 mol), AD-mix-α (43.5 g), and CH3SO2NH2 (3a, 3 g, 0.032 mol) in tert-butyl alcohol-water (120 mL:120 mL). The reaction mixture was quenched with sodium sulfite (31.1 g). After purification, 4.51 g (78%) of the (S)-10a was isolated. Characterization data is similar with data reported in Fang, Q. K.; Han, Z.; Grover, P.; Kessler, D.; Senanayake, C. H.; Wald, S. A., Tetrahedron: Asymmetry 2000, 11, 3659-3663.

WORKUP

后处理

customCompound (S)-10a was synthesized by a procedure similar to
customThe reaction mixture was quenched with sodium sulfite (31.1 g)
customAfter purification, 4.51 g (78%) of the (S)-10a
customwas isolated