HCID 50996264, compound → HCID 50997510, compound

Participants

Reaction Steps

To a suspension of (E)-methyl 2-(4-methyl-6-phenyl-2-styrylpyrimidin-5-yl)pentanoate (91 mg; 0.235 mmol) in ethanol (2 mL) was added 10% Pd/C. The solution was deoxygenated and back filled with a nitrogen atmosphere twice. The solution was then degassed, back filled with hydrogen gas and allowed to react at room temperature overnight. The reaction mixture was filtered using a syringe filter and the solvent was removed under reduced pressure. The crude material was purified by flash chromatography on silica gel using a linear gradient of ethylacetate (5-30%) in heptane to give 91 mg of the title compound which was immediately used in the next step. ESI/APCI(+): 389 (M+H).

Provenance & Evidence