Hydrochloric Acid → HCID 50996967, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(4-(3-(methoxymethoxy)phenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (60 mg; 0.143 mmol) was dissolved in methanol (1.5 mL) and 12N hydrochloric acid (10 μL; 0.120 mmol) was added. The mixture was heated at 60° C. for 3 h until the deprotection was finished (monitored by TLC). The mixture was basified with an excess 10N sodium hydroxide solution and stirred in a sealed tube at 80° C. for 18 h. The volatiles were removed under reduced pressure, the residue was dissolved in water and acidified with a 6N hydrochloric acid solution. The precipitate was filtered, washed with water and dried under reduced pressure over phosphorus pentoxide to give 37 mg (71%) of the title compound as a yellowish solid. ESI/APCI(+): 363 (M+H). ESI/APCI(−): 723 (2M−H).

Provenance & Evidence