Pyrrolidine → Methyl 2-(4-methyl-2-(pyrrolidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Methyl 2-(4-methyl-2-(pyrrolidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate was prepared according to the general method A starting from pyrrolidine (0.111 mL; 1.32 mmol) and methyl 2-(2-chloro-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate (0.110 g; 0.264 mmol) in tetrahydrofuran (2 mL). Purification by flash-chromatography on silica gel using a gradient of ethyl acetate (5-20%) in heptane furnished 90 mg (93%) of the title compound as an oil. ESI/APCI(+): 368 (M+H), 390 (M+Na). ESI/APCI(−): 366 (M−H).

Provenance & Evidence